UvA - DARE ( Digital Academic Repository ) Selective decontamination of the digestive tract reduces mortality in critically ill patients
نویسنده
چکیده
Several emotional responses may be invoked in critical care physicians when confronted with selective decontamination of the digestive tract (SDD). Although recent meta-analyses have shown that the use of SDD reduces the occurrence of ventilator-associated pneumonia and improves ICU survival, the effectiveness of SDD has remained controversial. We recently concluded a large randomized, controlled trial on the use of SDD that showed improved survival of ICU patients treated with SDD. A second concern regarding use of SDD has been the fear for the emergence of antimicrobial resistance. Interestingly, a recently published study did not confirm this fear, and our recently finished study even demonstrated a decline in colonization with P. aeruginosa and enterobacteriaceae that were resistant against tobramycin, ceftazidime, imipenem and ciprofloxacin. The hopes are that this study will at long last end the debate about the efficacy and safety of SDD in critically ill patients.
منابع مشابه
Selective decontamination of the digestive tract in surgical patients: a systematic review of the evidence.
OBJECTIVE To determine the comparative efficacy of selective decontamination of the digestive tract in critically ill surgical and medical patients, and in selected subgroups of surgical patients with pancreatitis, major burn injury, and those undergoing major elective surgery and transplantation. DATA SOURCES The MEDLINE database was searched from January 1966 to December 1996 using the term...
متن کاملSelective decontamination of the digestive tract reduces mortality in critically ill patients
Several emotional responses may be invoked in critical care physicians when confronted with selective decontamination of the digestive tract (SDD). Although recent meta-analyses have shown that the use of SDD reduces the occurrence of ventilator-associated pneumonia and improves ICU survival, the effectiveness of SDD has remained controversial. We recently concluded a large randomized, controll...
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Selective decontamination of the digestive tract has been proven to prevent severe infections and to reduce mortality in critically ill patients. Historical arguments against its use, like the development of bacterial resistance and the absence of influence on mortality, have not been confirmed. Recent clinical trials designed to evaluate these variables and meta-analyses showed remarkable redu...
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Background: Infectious complications remain a major concern in critically ill patients. Preventive measures are clearly better than treatment. Selective decontamination (SDD) of the upper digestive tract is one method that has had mixed results. Numerous questions exist as to whether or not gastrointestinal (GI) decontamination should be routine or not. Objective: To determine the effectiveness...
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